Scientific Literature | Bone Repair and Formation

This list revised March 15, 2009.   If you wish, you may download a PDF document containing this information.

  • 1. Andrew JG, Hoyland JA, Freemont AJ, Marsh DR. Platelet-derived growth factor expression in normally healing human fractures. Bone. 1995 Apr;16(4):455-60.
  • 2. Arm DM, Tencer AF, Bain SD, Celino D. Effect of controlled release of platelet-derived growth factor from a porous hydroxyapatite implant on bone ingrowth. Biomaterials. 1996 Apr;17(7):703-9.
  • 3. Al-Zube L, Breitbart EA, O'Connor JP, Parsons JR, Bradica G, Hart CE, Lin SS. Recombinant human platelet-derived growth factor BB (rhPDGF-BB) and beta-tricalcium phosphate/collagen matrix enhance fracture healing in a diabetic rat model. J Orthop Res. 2009 Jan 23.
  • 4. Bolander ME. Regulation of fracture repair by growth factors. Proc Soc Exp Biol Med. 1992 Jun;200(2):165-70.
  • 5. Bouletreau PJ, Warren SM, Spector JA, Steinbrech DS, Mehrara BJ, Longaker MT. Factors in the fracture microenvironment induce primary osteoblast angiogenic cytokine production. Plast Reconstr Surg. 2002 Jul;110(1):139-48.
  • 6. Bourque WT, Gross M, Hall BK. Expression of four growth factors during fracture repair. Int J Dev Biol. 1993 Dec;37(4):573-9.
  • 7. Cenni E, Savarino L, Antonioli D, Pellacani A, Giunti A, Baldini N. Plasma levels of platelet-derived growth factor BB and transforming growth factor in patients with failed hip prostheses. Acta Orthop. 2005 Feb;76(1):61-6.
  • 8. Centrella M, McCarthy TL, Kusmik WF, Canalis E. Relative binding and biochemical effects of heterodimeric and homodimeric isoforms of platelet-derived growth factor in osteoblast-enriched cultures from fetal rat bone. J Cell Physiol. 1991 Jun;147(3):420-6.
  • 9. Devescovi V, Leonardi E, Ciapetti G, Cenni E. Growth factors in bone repair. Chir Organi Mov. 2008 Dec;92(3):161-8.
  • 10. Fiedler J, Etzel N, Brenner RE. To go or not to go: Migration of human mesenchymal progenitor cells stimulated by isoforms of PDGF. J Cell Biochem. 2004 Nov 15;93(5):990- 8.
  • 11. Fiedler J, Röderer G, Günther KP, Brenner RE. BMP-2, BMP-4, and PDGF-bb stimulate chemotactic migration of primary human mesenchymal progenitor cells. J Cell Biochem. 2002;87(3):305-12.
  • 12. Geng T, Sun H, Luo F, Qi N. Quantitative analysis of the responses of murine bone marrow mesenchymal stem cells to EGF, PDGF-BB and fibronectin by factorial design methodology. Cytotechnology. 2008 Oct;58(2):93-101.
  • 13. Goodkin DA, Pierce GF. Role of platelet-derived growth factor in osteoblast function and bone synthesis. Wound Repair Regen. 1993 Oct;1(4):203-12.
  • 14. Gruber R, Karreth F, Frommlet F, Fischer MB, Watzek G. Platelets are mitogenic for periosteum-derived cells. J Orthop Res. 2003 Sep;21(5):941-8.
  • 15. Gruber R, Varga F, Fischer MB, Watzek G. Platelets stimulate proliferation of bone cells: involvement of platelet-derived growth factor, microparticles and membranes. Clin Oral Implants Res. 2002 Oct;13(5):529-35.
  • 16. Heldin CH. Platelet-derived growth factor--an introduction. Cytokine Growth Factor Rev. 2004 Aug;15(4):195-6.
  • 17. Heldin CH, Eriksson U, Ostman A. New members of the platelet-derived growth factor family of mitogens. Arch Biochem Biophys. 2002 Feb 15;398(2):284-90.
  • 18. Heldin CH, Westermark B. Mechanism of action and in vivo role of platelet-derived growth factor. Physiol Rev. 1999 Oct;79(4):1283-316.
  • 19. Heldin CH, Ostman A, Rönnstrand L. Signal transduction via platelet-derived growth factor receptors. Biochim Biophys Acta. 1998 Aug 19;1378(1):F79-113.
  • 20. Hock JM, Canalis E. Platelet-derived growth factor enhances bone cell replication, but not differentiated function of osteoblasts. Endocrinology. 1994 Mar;134(3):1423-8.
  • 21. Hollinger JO, Hart CE, Hirsch SN, Lynch S, Friedlaender GE. Recombinant human platelet- derived growth factor: biology and clinical applications. J Bone Joint Surg Am. 2008 Feb; 90 Suppl 1:48-54.
  • 22. Hollinger JO, Onikepe AO, MacKrell J, Einhorn T, Bradica G, Lynch S, Hart CE. Accelerated fracture healing in the geriatric, osteoporotic rat with recombinant human platelet-derived growth factor-BB and an injectable beta-tricalcium phosphate/collagen matrix. J Orthop Res. 2008 Jan;26(1):83-90.
  • 23. Horner A, Bord S, Kemp P, Grainger D, Compston JE. Distribution of platelet-derived growth factor (PDGF) A chain mRNA, protein, and PDGF-alpha receptor in rapidly forming human bone. Bone. 1996 Oct; 19(4):353-62.
  • 24. Howes R, Bowness JM, Grotendorst GR, Martin GR, Reddi AH. Platelet-derived growth factor enhances demineralized bone matrix-induced cartilage and bone formation. Calcif Tissue Int. 1988 Jan;42(1):34-8.
  • 25. Hsieh SC, Graves DT. Pulse application of platelet-derived growth factor enhances formation of a mineralizing matrix while continuous application is inhibitory. J Cell Biochem. 1998 May 1; 69(2):169-80.
  • 26. Huang Z, Nelson ER, Smith RL, Goodman SB. The sequential expression profiles of growth factors from osteoprogenitors to osteoblasts in vitro. Tissue Eng. 2007 Sep;13(9):2311-20.
  • 27. Hughes FJ, Aubin JE, Heersche JN. Differential chemotactic responses of different populations of fetal rat calvaria cells to platelet-derived growth factor and transforming growth factor beta. Bone Miner. 1992 Oct; 19(1):63-74.
  • 28. Kilian O, Alt V, Heiss C, Jonuleit T, Dingeldein E, Flesch I, Fidorra U, Wenisch S, Schnettler R. New blood vessel formation and expression of VEGF receptors after implantation of platelet growth factor-enriched biodegradable nanocrystalline hydroxyapatite. Growth Factors. 2005 Jun; 23(2):125-33.
  • 29. Kilian O, Flesch I, Wenisch S, Taborski B, Jork A, Schnettler R, Jonuleit T. Effects of platelet growth factors on human mesenchymal stem cells and human endothelial cells in vitro. Eur J Med Res. 2004 Jul 30;9(7):337-44.
  • 30. Kim HD, Valentini RE. Human osteoblast response in vitro to platelet-derived growth factor and transforming growth factor-beta delivered from controlled-release polymer rods. Biomaterials. 1997 Sep; 18(17):1175-84.
  • 31. Kubota K, Sakikawa C, Katsumata M, Nakamura T, Wakabayashi K. Platelet-derived growth factor BB secreted from osteoclasts acts as an osteoblastogenesis inhibitory factor. J Bone Miner Res. 2002 Feb; 17(2):257-65.
  • 32. Lee JY, Nam SH, Im SY, Park YJ, Lee YM, Seol YJ, Chung CP, Lee SJ. Enhanced bone formation by controlled growth factor delivery from chitosan-based biomaterials. J Control Release. 2002 Jan 17; 78(1-3):187-97.
  • 33. Lee SJ, Park YJ, Park SN, Lee YM, Seol YJ, Ku Y, Chung CP. Molded porous poly (L-lactide) membranes for guided bone regeneration with enhanced effects by controlled growth factor release. J Biomed Mater Res. 2001 Jun 5;55(3):295-303.
  • 34. Lee YM, Park YJ, Lee SJ, Ku Y, Han SB, Choi SM, Klokkevold PR, Chung CP. Tissue engineered bone formation using chitosan/tricalcium phosphate sponges. J Periodontol. 2000 Mar; 71(3): 410-7.
  • 35. Lind M, Deleuran B, Thestrup-Pedersen K, Soballe K, Eriksen EF, Bunger C. Chemotaxis of human osteoblasts. Effects of osteotropic growth factors. AIPMIS. 1995 Feb; 103(2): 140-6.
  • 36. McCarthy HS, Williams JH, Davie MW, Marshall MJ. Platelet-derived growth factor stimulates osteoprotegerin production in osteoblastic cells. J Cell Physiol. 2009 Feb; 218(2): 350-4.
  • 37. Mehrotra M, Krane SM, Walters K, Pilbeam C. Differential regulation of platelet-derived growth factor stimulated migration and proliferation in osteoblastic cells. J Cell Biochem. 2004 Nov 1; 93(4): 741-52.
  • 38. Mitlak BH, Finkelman RD, Hill EL, Li J, Martin B, Smith T, D'Andrea M, Antoniades HN, Lynch SE. The effect of systemically administered PDGF-BB on the rodent skeleton. J Bone Miner Res. 1996 Feb; 11(2): 238-47.
  • 39. Mott DA, Mailhot J, Cuenin MF, Sharawy M, Borke J. Enhancement of osteoblast proliferation in vitro by selective enrichment of demineralized freeze-dried bone allograft with specific growth factors. J Oral Implantol. 2002; 28(2): 57-66.
  • 40. Nash TJ, Howlett CR, Martin C, Stee!e J, Johnson KA, Hicklin DJ. Effect of platelet-derived growth factor on tibial osteotomies in rabbits. Bone. 1994 Mar-Apr; 15(2): 203-8.
  • 41. Oreffo RO. Growth factors for skeletal reconstruction and fracture repair. Curr Opin Investig Drugs. 2004 Apr; 5(4): 419-23.
  • 42. Ozaki Y, Nishimura M, Sekiya K, Suehiro F, Kanawa M, Nikawa H, Hamada T, Kato Y. Comprehensive analysis of chemotactic factors for bone marrow mesenchymal stem cells. Stem Cells Dev. 2007 Feb; 16(1): 119-29.
  • 43. Ranly DM, McMillan J, Keller T, Lohmann CH, Meunch T, Cochran DL, Schwartz Z, Boyan BD. Platelet-derived growth factor inhibits demineralized bone matrix-induced intramuscular cartilage and bone formation. A study of immunocompromised mice. J Bone Joint Surg Am. 2005 Sep; 87(9): 2052-64.
  • 44. Ross R, Raines EW, Bowen-Pope DF. The biology of platelet-derived growth factor. Cell. 1986 Jul 18;46(2):155-69.
  • 45. Rydziel S, Shaikh S, Canalis E. Platelet-derived growth factor-AA and -BB (PDGF-AA and - BB enhance the synthesis of PDGF-AA in bone cell cultures). Endocrinology. 1994 Jun;134(6):2541-6.
  • 46. Sanchez-Fernandez MA, Gallois A, Riedl T, Jurdic P, Hoflack B. Osteoclasts control osteoblast chemotaxis via PDGF-BB/PDGF receptor beta signaling. PLoS ONE. 2008; 3(10): e3537. Epub 2008 Oct 27.
  • 47. Tanaka H, Wakisaka A, Ogasa H, Kawai S, Liang CT. Effect of IGF-I and PDGF administered in vivo on the expression of osteoblast-related genes in old rats. J Endocrinol. 2002 Jul; 174(1): 63-70.
  • 48. Tokunaga A, Oya T, Ishii Y, Motomura H, Nakamura C, Ishizawa S, Fujimori T, Nabeshima Y, Umezawa A, Kanamori M, Kimura T, Sasahara M. PDGF receptor beta is a potent regulator of mesenchymal stromal cell function. J Bone Miner Res. 2008 Sep; 23(9): 1519-28.
  • 49. Tsukamoto T, Matsui T, Fukase M, Fujita T. Platelet-derived growth factor B chain homodimer enhances chemotaxis and DNA synthesis in normal osteoblast-like cells. Biochem Biophys Res Commun. 1991 Mar 29; 175(3): 745-51.
  • 50. Tyndall WA, Beam HA, Zarro C, O'Connor JP, Lin SS. Decreased platelet derived growth factor expression during fracture healing in diabetic animals. Clin Orthop Relat Res. 2003 Mar; (408): 319-30.
  • 51. Vikjaer D, Blom S, Hjørting-Hansen E, Pinholt EM. Effect of platelet-derived growth factor-BB on bone formation in calvarial defects: an experimental study in rabbits. Eur J Oral Sci. 1997 Feb; 105(1): 59-66.
  • 52. Vladimirov BS, Dimitrov SA. Growth factors--importance and possibilities for enhancement of the healing process in bone fractures. Folia Med (Plovdiv). 2004; 46(2): 11-7.
  • 53. Weiss S, Zimmermann G, Pufe T, Varoga D, Henle P. The systemic angiogenic response during bone healing. Arch Orthop Trauma Surg. 2008 Nov 27.
  • 54. Yang D, Chen J, Jing Z, Jin D. Platelet-derived growth factor (PDGF)-AA: a self-imposed cytokine in the proliferation of human fetal osteoblasts. Cytokine. 2000 Aug; 12(8): 1271-4.
  • 55. Yu X, Hsieh SC, Bao W, Graves DT. Temporal expression of PDGF receptors and PDGF regulatory effects on osteoblastic cells in mineralizing cultures. Am J Physiol. 1997 May; 272(5 Pt 1): C1709-16.
  • 56. Zhang L, Leeman E, Carnes DC, Graves DT. Human osteoblasts synthesize and respond to platelet-derived growth factor. Am J Physiol. 1991 Aug; 261(2 Pt 1): C348-54.
  • 57. Zhang Z, Chen J, Jin D. Platelet-derived growth factor (PDGF)-BB stimulates osteoclastic bone resorption directly: the role of receptor beta. Biochem Biophys Res Commun. 1998 Oct 9; 251(1): 190-4.