Scientific Literature | Sports Medicine

This list revised March 15, 2009.   If you wish, you may download a PDF document containing this information.

  • 1. Banes AJ, Tsuzaki M, Hu P, Brigman B, Brown T, Almekinders L, Lawrence WT, Fischer T. PDGF-BB, IGF-I and mechanical load stimulate DNA synthesis in avian tendon fibroblasts in vitro. J Biomech. 1995 Dec; 28(12): 1505-13.
  • 2. Batten ML, Hansen JC, Dahners LE. Influence of dosage and timing of application of platelet-derived growth factor on early healing of the rat medial collateral ligament. J Orthop Res. 1996 Sep; 14(5): 736-41.
  • 3. Benz K, Breit S, Lukoschek M, Mau H, Richter W. Molecular analysis of expansion, differentiation, and growth factor treatment of human chondrocytes identifies differentiation markers and growth-related genes. Biochem Biophys Res Commun. 2002 Apr 26; 293(1): 284-92.
  • 4. Bhargava MM, Hidaka C, Hannafin JA, Doty S, Warren RF. Effects of hepatocyte growth factor and platelet-derived growth factor on the repair of meniscal defects in vitro. In Vitro Cell Dev Biol Anim. 2005 Sep-Oct; 41(8-9): 305-10.
  • 5. Bhargava MM, Attia ET, Murrell GA, Dolan MM, Warren RF, Hannafin JA. The effect of cytokines on the proliferation and migration of bovine meniscal cells. Am J Sports Med. 1999 Sep-Oct; 27(5): 636-43.
  • 6. Cassiede P, Dennis JE, Ma F, Caplan AI. Osteochondrogenic potential of marrow mesenchymal progenitor cells exposed to TGF-beta 1 or PDGF-BB as assayed in vivo and in vitro. J Bone Miner Res. 1996 Sep; 11(9): 1264-73.
  • 7. Chaipinyo K, Oakes BW, van Damme MP. Effects of growth factors on cell proliferation and matrix synthesis of low-density, primary bovine chondrocytes cultured in collagen I gels. J Orthop Res. 2002 Sep; 20(5): 1070-8.
  • 8. Costa MA, Wu C, Pham BV, Chong AK, Pham HM, Chang J. Tissue engineering of flexor tendons: optimization of tenocyte proliferation using growth factor supplementation. Tissue Eng. 2006 Jul; 12(7): 1937-43.
  • 9. Duffy FJ Jr, Seiler JG, Gelberman Ru, Hergrueter CA. Growth factors and canine flexor tendon healing: initial studies in uninjured and repair models. J Hand Surg [Am]. 1995 Jul; 20(4): 645-9.
  • 10. Gelberman RH, Thomopoulos S, Sakiyama-Elbert SE, Das R, Silva MJ. The early effects of sustained platelet-derived growth factor administration on the functional and structural properties of repaired intrasynovial flexor tendons: an in vivo biomechanic study at 3 weeks in canines. J Hand Surg [Am]. 2007 Mar; 32(3): 373-9.
  • 11. Haupt JL, Donnelly BP, Nixon AJ. Effects of platelet-derived growth factor-BB on the metabolic function and morphologic features of equine tendon in explant culture. Am J Vet Res. 2006 Sep; 67(9): 1595-600.
  • 12. Hildebrand KA, Woo SL, Smith DW, Allen CR, Deie M, Taylor BJ, Schmidt CC. The effects of platelet-derived growth factor-BB on healing of the rabbit medial collateral ligament. An in vivo study. Am J Sports Med. 1998 Jul-Aug; 26(4): 549-54.
  • 13. Hsu C, Chang J. Clinical implications of growth factors in flexor tendon wound healing. J Hand Surg [Am]. 2004 Jul; 29(4): 551-63.
  • 14. Huith A, Johnell 0, Miyazono K, Lindberg L, Heinegard D, Heldin CII. Effect of transforming growth factor-beta and platelet-derived growth factor-BB on articular cartilage in rats. J Orthop Res. 1996 Jul; 14(4): 547-53.
  • 15. Jakob M, Démarteau O, Schäfer D, Hintermann B, Dick W, Heberer M, Martin I. Specific growth factors during the expansion and redifferentiation of adult human articular chondrocytes enhance chondrogenesis and cartilaginous tissue formation in vitro. J Cell Biochem. 2001 Mar 26; 81(2): 368-77.
  • 16. Kang HJ, Kang ES. Ideal concentration of growth factors in rabbit's flexor tendon culture. Yonsei Med J. 1999 Feb; 40(1): 26-9.
  • 17. Lee J, Harwood FL, Akeson WH, Amiel D. Growth factor expression in healing rabbit medial collateral and anterior cruciate ligaments. Iowa Orthop J. 1998; 18: 19-25.
  • 18. Lietman SA, Hobbs W, Inoue N, Reddi AH. Effects of selected growth factors on porcine meniscus in chemically defined medium. Orthopedics. 2003 Aug; 26(8): 799-803.
  • 19. Letson AK, Dahners LE. The effect of combinations of growth factors on ligament healing. Clin Orthop. 1994 Nov;(308): 207-12
  • 20. Ljung A, Skoog V, Widenfalk B, Ren Z, Nistér M, Ohlsén L. Expression of platelet-derived growth factor beta receptor in chondrogenesis of perichondrial transplants. Scand J Plast Reconstr Surg Hand Surg. 1995 Dec; 29(4): 289-95.
  • 21. Lohmann CH, Schwartz Z, Niederauer GG, Carnes DL Jr, Dean DD, Boyan BD. Pretreatment with platelet derived growth factor-BB modulates the ability of costochondral resting zone chondrocytes incorporated into PLA/PGA scaffolds to form new cartilage in vivo. Biomaterials. 2000 Jan; 21(1): 49-61.
  • 22. Mishima Y, Lotz M. Chemotaxis of human articular chondrocytes and mesenchymal stem cells. J Orthop Res. 2008 Oct; 26(10): 1407-12.
  • 23. Molloy T, Wang Y, Murrell G. The roles of growth factors in tendon and ligament healing. Sports Med. 2003; 33(5): 381-94.
  • 24. Nakamura N, Shino K, Natsuume T, Horibe S, Matsumoto N, Kaneda Y, Ochi T. Early biological effect of in vivo gene transfer of platelet-derived growth factor (PDGF)-B into healing patellar ligament. Gene Ther. 1998 Sep; 5(9): 1165-70.
  • 25. Petersen W, Pufe T, Zantop T, Tillmann B, Mentlein R. Hypoxia and PDGF have a synergistic effect that increases the expression of the angiogenetic peptide vascular endothelial growth factor in Achilles tendon fibroblasts. Arch Orthop Trauma Surg. 2003 Nov; 123(9): 485-8.
  • 26. Rousche KT, Ford BC, Praul CA, Leach RM. The use of growth factors in the proliferation of avian articular chondrocytes in a serum-free culture system. Connect Tissue Res. 2001; 42(3): 165-74.
  • 27. Sakiyama-Elbert SE, Das R, Gelberman RH, Harwood F, Amiel D, Thomopoulos S. Controlled-release kinetics and biologic activity of platelet-derived growth factor-BB for use in flexor tendon repair. J Hand Surg [Am]. 2008 Nov; 33(9): 1548-57.
  • 28. Schmidt MB, Chen EH, Lynch SE. A review of the effects of insulin-like growth factor and platelet derived growth factor on in vivo cartilage healing and repair. Osteoarthritis Cartilage. 2006 May; 14(5): 403-12.
  • 29. Spindler KP, Imro AK, Mayes CE, Davidson JM. Patellar tendon and anterior cruciate ligament have different mitogenic responses to platelet-derived growth factor and transforming growth factor beta. J Orthop Res. 1996 Jul; 14(4): 542-6.
  • 30. Spindler KP, Mayes CE, Miller RR, Imro AK, Davidson JM. Regional mitogenic response of the meniscus to platelet-derived growth factor (PDGF-AB). J Orthop Res. 1995 Mar;13(2):201-7.
  • 31. Spindler KP, Nanney LB, Davidson JM. Proliferative responses to platelet-derived growth factor in young and old rat patellar tendon. Connect Tissue Res. 1995; 31(2): 171-7.
  • 32. Stein LE. Effects of serum, fibroblast growth factor, and platelet-derived growth factor on explants of rat tail tendon: a morphological study. Acta Anat (Basel). 1985; 123(4): 247-52.
  • 33. Stewart K, Pabbruwe M, Dickinson S, Sims T, Hollander AP, Chaudhuri JB. The effect of growth factor treatment on meniscal chondrocyte proliferation and differentiation on polyglycolic acid scaffolds. Tissue Eng. 2007 Feb; 13(2): 271-80.
  • 34. Suzuki K, Attia ET, Hannafin JA, Rodeo SA, Warren RF, Bhargava MM. The effect of cytokines on the migration of fibroblasts derived from different regions of the canine shoulder capsule. J Shoulder Elbow Surg. 2001 Jan-Feb; 10(1): 62-7.
  • 35. Thomopoulos S, Zaegel M, Das R, Harwood FL, Silva MJ, Amiel D, Sakiyama-Elbert S, Gelberman RH. PDGF-BB released in tendon repair using a novel delivery system promotes cell proliferation and collagen remodeling. J Orthop Res. 2007 Oct; 25(10): 1358-68.
  • 36. Thomopoulos S, Harwood FL, Silva MJ, Amiel D, Gelberman RH. Effect of several growth factors on canine flexor tendon fibroblast proliferation and collagen synthesis in vitro. J Hand Surg [Am]. 2005 May; 30(3): 441-7.
  • 37. Tsubone T, Moran SL, Amadio PC, Zhao C, An KN. Expression of growth factors in canine flexor tendon after laceration in vivo. Ann Plast Surg. 2004 Oct; 53(4): 393-7.
  • 38. Uggen JC, Dines J, Uggen CW, Mason JS, Razzano P, Dines D, Grande DA. Tendon gene therapy modulates the local repair environment in the shoulder. J Am Osteopath Assoc. 2005 Jan; 105(1): 20-1.
  • 39. Visnapuu V, Peltomäki T, Rönning O, Vahlberg T, Helenius H. Distribution of fibroblast growth factors (FGFR-1 and -3) and platelet-derived growth factor receptors (PDGFR) in the rat mandibular condyle during growth. Orthod Craniofac Res. 2002 Aug; 5(3): 147- 53.
  • 40. Weiler A, Förster C, Hunt P, Falk R, Jung T, Unterhauser FN, Bergmann V, Schmidmaier G, Haas NP. The influence of locally applied platelet-derived growth factor-BB on free tendon graft remodeling after anterior cruciate ligament reconstruction. Am J Sports Med. 2004 Jun; 32(4): 881-91.
  • 41. Weiser L, Bhargava M, Attia E, Torzilli PA. Effect of serum and platelet-derived growth factor on chondrocytes grown in collagen gels. Tissue Eng. 1999 Dec; 5(6): 533-44.
  • 42. Woo SL, Smith DW, Hildebrand KA, Zeminski JA, Johnson LA.Engineering the healing of the rabbit medial collateral ligament. Med Biol Eng Comput. 1998 May; 36(3): 359-64.
  • 43. Würgler-Hauri CC, Dourte LM, Baradet TC, Williams GR, Soslowsky LJ. Temporal expression of 8 growth factors in tendon-to-bone healing in a rat supraspinatus model. J Shoulder Elbow Surg. 2007 Sep-Oct; 16(5 Suppl): S198-203.
  • 44. Wroblewski J, Edwall C. PDGF BB stimulates proliferation and differentiation in cultured chondrocytes from rat rib growth plate. Cell Biol Int Rep. 1992 Feb; 16(2): 133-44.
  • 45. Yoshikawa Y, Abrahamsson SO. Dose-related cellular effects of platelet-derived growth factor-BB differ in various types of rabbit tendons in vitro. Acta Orthop Scand. 2001 Jun; 72(3): 287-92.